BAH!
You can make LS Commander work on the Mac. First, you cannot be running LScript 2.5.1, it must be 2.5, so if you've upgraded, replace the Lcore3.shlib with the original from the CD. Second, you will need to make sure your disk permissions are corrected in OS X. (Applications:Utilities

isk Utility - First Aid).
Third, you will need to delete any preference file that is related to LScript:
LScprit Prefs, LS/GN Prefs, etc.
At this point, LS Commander should work fine. If, for some reason, it fails again in the future, just remove the LScript specific preference files and try again.